DESIGN AND CHARACTERIZATION OF VALSARTAN NANO SUSPENSION
Rajalakshmi. R
Dept. of Pharmaceutics, Sree Vidyanikethan College of Pharmacy, Tirupati, A.P, 517102, India.
Thanda Venkataramudu
Dept. of Pharmaceutics, Sree Vidyanikethan College of Pharmacy, Tirupati, A.P, 517102, India.
R. Arun Kumar
Dept. of Pharmaceutics, Sree Vidyanikethan College of Pharmacy, Tirupati, A.P, 517102, India.
K. Divya Sree
Dept. of Pharmaceutics, SV University, Tirupati, A.P, 517102, India.
M. Deepti Kiranmayi
Dept. of Pharmaceutics, AMR Memorial College of Pharmacy, Narasaraopet, Guntur, A.P, 522601, India.
Low oral bioavailability of poorly water soluble drugs poses a great challenge during drug development. Poorly water soluble compounds are difficult to develop as drug products and conventional formulation techniques are frequently abandoned early in discovery. The aim of the present study was to improve the dissolution rate of a poorly water soluble drug, valsartan, by a high pressure homogenization technique. Six different formulations were prepared by optimizing various parameters using different polymers like polaxamer, soyalecithin, PVP and PVA. Formulations are evaluated for pure drug identification, FTIR, DSC, %yield, drug content, %EE, SEM, In vitro drug release study. Polymer concentrations have greater effect on retention of nanosuspension and control the drug release for longer period. From the results of all the formulations F3 exhibited optimum characters.
2 , 2 , 2012
70 - 81