Issn  2249-7579
e Issn  2249-7579
Publisher JOURNAL OF PHARMACEUTICAL BIOLOGY

PH-RESPONSIVE SEMI- INTERPENETRATING POLYMERIC HYDROGELS MICROSPHERES OF CHITOSAN AND POLY VINYL ALCOHOL FOR IN –VITRO CONTROLLED RELEASE OF CLARITHROMYCIN

Department of Pharmacognosy and Phytochemistry, Sree Vidyanikethan College of Pharmacy, Tirupathi-517102, Andhra Pradesh, India.
Department of Pharmacognosy and Phytochemistry, Sree Vidyanikethan College of Pharmacy, Tirupathi-517102, Andhra Pradesh, India.
Department of Pharmacognosy and Phytochemistry, Sree Vidyanikethan College of Pharmacy, Tirupathi-517102, Andhra Pradesh, India.
Department of Pharmacognosy and Phytochemistry, Sree Vidyanikethan College of Pharmacy, Tirupathi-517102, Andhra Pradesh, India.
Department of Pharmacognosy and Phytochemistry, Sree Vidyanikethan College of Pharmacy, Tirupathi-517102, Andhra Pradesh, India.
Department of Pharmacognosy and Phytochemistry, Sree Vidyanikethan College of Pharmacy, Tirupathi-517102, Andhra Pradesh, India.

pH – responsive biodegradable semi- interpenetrating polymeric network (semi- IPN) hydrogels microspheres based on Chitosan and PVA were prepared and Characterized for the controlled drug release investigations. Glutraldehyde was used as a crosslinking agent. The equilibrium swelling Characteristics were investigated for the hydrogel microspheres at 370C in buffer solution at pH 2.1 (simulated gastric fluid, SGF) and pH 7.4 simulated intestinal fluid, SIF). Clarithromycin was entrapped in the hydrogels for stomach-specific drug delivery system for controlled release of drug for eradication of Helicobacter pylori (H. pylori); in vitro release profiles of the drug were established at 370 C at pH 2.1 and pH 7.4. FTIR, SEM was used to characterize hydrogels.

4 , 2 , 2014

68 - 73