Issn  2249-7579
e Issn  2249-7579
Publisher JOURNAL OF PHARMACEUTICAL BIOLOGY

ANTI-CONVULSANT EFFECT OF BARRINGTONIA ACUTANGULA EXTRACT ON MES INDUCED CONVULSION IN RATS

Department of Pharmacognosy and Phytochemistry, Sree Vidyanikethan College of Pharmacy, Tirupathi-517102, Andhra Pradesh, India.
Department of Pharmacognosy and Phytochemistry, Sree Vidyanikethan College of Pharmacy, Tirupathi-517102, Andhra Pradesh, India.
Department of Pharmacognosy and Phytochemistry, Sree Vidyanikethan College of Pharmacy, Tirupathi-517102, Andhra Pradesh, India.
Department of Pharmacognosy and Phytochemistry, Sree Vidyanikethan College of Pharmacy, Tirupathi-517102, Andhra Pradesh, India.
Department of Pharmacognosy and Phytochemistry, Sree Vidyanikethan College of Pharmacy, Tirupathi-517102, Andhra Pradesh, India.
Department of Pharmacognosy and Phytochemistry, Sree Vidyanikethan College of Pharmacy, Tirupathi-517102, Andhra Pradesh, India.

The present study is an investigation of anti-seizure activity of Barringtonia acutangula (L.) Gaertn. (Family: Lecythidaceae) an evergreen tree which is being used in Indian traditional medicines for treating epilepsy, diarrhoea, dysentery, cholera and ulcers. The ethanol extract of Barringtonia acutangula (EEBA) was subjected to acute toxicity and then screened for anticonvulsant activity on Maximal Electroshock (MES) model in albino wistar rats. Acute toxicity of extract was non toxic up to the recommended dose 2000 mg/kg. p.o. Animals were treated with EEBA at doses of 250 and 500 mg/kg body weight. Study results showed, the mean duration of extensor phase of treated groups reduced significant level than compared to control group. However, further studies still needed to be carried on exposure of the extract to humans.

4 , 2 , 2014

86 - 88