EVALUATION OF ANTI-EPILEPTIC EFFECT OF METHANOLIC EXTRACTS OF EUODIA HORTENSIS FORSTER
Deena Dalith M
Victoria College of Pharmacy, Nallapadu, Guntur, Andhra Pradesh, India.
Bhanu Prasad K
School of Pharmacy and Technology, Jawaharlal Nehru Technological University Kakinada, Andhra Pradesh, India.
The present report is an investigation of antiseizure activity of Euodia hortensis Forster .(Family - Rutaceae) which is probably native to New Guinea, and now widely distributedin the South Pacific.The methanolic (90%) extract of Euodia hortensis Forster. (MEEH) was subjected to acute toxicity and then screened for antiepileptic activity on Maximal Electroshock (MES) and Pentylenetetrazole (PTZ) induced seizures models in albino wistar rats. Acute toxicity of extract was non toxic up to the recommended dose 2000mg/kg body weight orally as per OECD guidelines No.423. Animals were pretreated with MEEH at the doses of 200 and 400mg/kg body weight. The study reported the significant delay in clonic seizure induced by PTZ and dose dependent decrease in duration of hindleg extensor phase in MES model. In MES model, MEEH showed significant reduction in duration of hindleg extension with 200 mg/kg dose and effect was dramatically reduced with 400mg/kg. Similar dose dependent results were obtained in PTZ model by delayed the onset of clonic convulsions. The complete protective effect against mortality was reported in both the tests. This study predicted possible mechanism of the formulation mediated through chloride channel of the GABA or benzodiazepine receptor complex .However, the exact mechanism of action is not clear, but attributed to its antiepileptic effect. The methanolic extract of Euodia hortensis Forster.deserves further investigation for detailed elucidation of active constituents and the mechanisms of action
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