Dengue is the most common mosquito borne viral infection (caused by Dengue type 1, Dengue type 2, Dengue type 3, and Dengue type 4 of the genus Flavivirus and Chikungunya virus) in Chennai, which had an outbreak due to seasonal and monsoon changes. Infection with one of the serotype provides immunity to only that serotype of life, to a person living in a Dengue-endemic area can have more than one Dengue infection during their lifetime. Its increasing prevalence is due partially to increased awareness and better diagnostic methods, because if it’s untreated, it can lead to fatal effects. We report a case of severe dengue fever with thrombocytopenia where the patient showed remarkable improvement upon treatment along with patient counseling.