Compare the efficacy and safety of Topical Ciprofloxacin with Topical Neomycin in Chronic Suppurative Otitis Media (CSOM) patients. A Retrospective observational study on CSOM patients who were treated with topical Ciprofloxacin or topical Neomycin with no loss of three weeks follow up are included in the study irrespective of their age and gender. CSOM patients undergone tympanoplasty and mastoidectomy (post operated CSOM patients) who were treated with Ciprofloxacin ear drops and Neomycin ear drops were also included in the study. The diagnostic parameters used were B/L X-ray Mastoids, Pure Tone Audiometry(PTA) and Impedance, other investigations include chest X-ray, coagulation profile, RBS, ECG.A total of 50 patients with diagnosis of Chronic Suppurative Otitis Media were selected for the study. Patients were categorized into 2 groups, Group A that was treated by topical Ciprofloxacin ear drops (n=25) and Group B that was treated by topical Neomycin ear drops (n=25). Outcomes were measured by disappearance of discharge and congestion at follow-up examination. SPSS 20 was used for data analysis, Chi-square test was used for analysis and P-value less than 0.05 were considered significant. Out of 50 subjects evaluated for the study 40% were male and remaining 60% were female. The age of patients varied from 15-67 years. The most prominent age group was found to be 31-40 years.The laterity in our study subjects shows that right ear was affected in 40%, left ear in 44% while 16% of the patients had bilaterally affected ears. Topical Ciprofloxacin is more effective in earlier control of discharge and congestion in CSOM patients as compared to Neomycin (p-value was obtained as <0.05). Ciprofloxacin otic drops areclinically more effective in the treatment of CSOM and can be used as an initial choice of topical antibiotic for CSOM patients.