This study aimed to analyze clinical features and prognostic factors to assist physicians in making clinical decisions regarding acute mesenteric ischemia (AMI). A retrospective analysis of 39 patients who underwent surgery for AMI was conducted using electronic medical records. Common comorbidities included hypertension and diabetes mellitus. AMI was the predominant presenting symptom, although other symptoms arose during unrelated hospitalizations. Initial assessments revealed low blood pressure and elevated pulse rates, with fever and shock reported in a subset of patients. Bowel resections and diagnostic laparotomies were performed, with an average recovery time of 13 days in the intensive care unit and 28.3 days in the hospital. Of the 39 patients, 56.1% showed improvements upon discharge, while 43.9% died. Death was associated with acute renal failure, elevated AST and ALT levels, abnormal bilirubin, and shock, contributing to chronic kidney disease. Logistic regression analysis indicated that AST and ALT levels were strongly predictive of mortality in AMI patients, suggesting abnormal liver function indices as potential prognostic markers. Despite study limitations, including a small sample size and retrospective design, this study provides valuable insights into potential prognostic factors for managing patients with AMI