Takayasu arteritis (TA) is a rare, chronic inflammatory large-vessel vasculitis affecting the aorta and its major branches, predominantly seen in young females. Objective To present a case of Takayasu arteritis with active inflammatory markers and emphasize the importance of early diagnosis and long-term management. Case Presentation. A 25-year-old female presented with generalized weakness and fatigue, with a known history of Takayasu arteritis diagnosed 6 years prior. Clinical examination revealed significant inter-arm blood pressure discrepancy, a characteristic feature of large vessel involvement [2]. Laboratory findings showed microcytic hypochromic anaemia and markedly elevated ESR, indicating active inflammation. Methods Clinical evaluation, laboratory investigations, and imaging findings were used to assess disease activity and progression. Results The patient demonstrated features of chronic inflammatory disease activity, including elevated ESR and vascular involvement. Imaging findings supported arterial wall inflammation, consistent with disease progression. Treatment included corticosteroids and immunosuppressants aimed at controlling inflammation and preventing complications. Conclusion Takayasu arteritis requires early recognition and continuous monitoring due to its relapsing nature and risk of severe complications. Laboratory markers along with imaging play a crucial role in assessing disease activity. Long-term multidisciplinary management improves patient outcomes and reduces morbidity