Antibiotics are common approach for the treatment of infectious diseases. There are two problems with antibiotics; mainly the first one includes the development of antibiotic resistance. Second they kill both good and bad bacteria. By killing beneficiary bacteria antibiotics can harmful for the digestive system. Many studies have been conducted to find out a way to destroy bad bacteria and not affect good bacteria. Hence microbiologists have developed an antibiotic smart bomb that can identify specific strains of bacteria and eliminates the infection. This paper reviews about the information regarding the antibiotic smart bomb in brief