Wound is a common surgical problem due to many reasons including injury. Many grades of wounds are managed by the patients themselves as a part of first aid measure and as home treatment. Wound infection is a major task for the doctors to treat especially when it is seen with diabetes, varicosity of leg veins or with the complications likes Cellulitis. Many topical antimicrobial creams are available in the market like Neomycin and Polymixin B fixed drug combination cream, Silversulphadiazine, Mupirocine, Povidone iodine alone or in combination with metronidazole /Secnidazole and few with enzymes etc. Povidone iodine is the most popular drug for wound cleaning, irrigation purpose and many people are using in first aid kit. As a mode of action, it kills germs, bacteria and few deeper infections. The combination of Povidone iodine with metronidazole is commonly used in surgical treatment for many superficial & deep wounds cleaning and healing purpose as equal with Povidone iodine alone. This study is mainly focused on the advantages of Povidone iodine with metronidazole as a fixed drug combinations in patients with the diagnosis of cellulitis due to ulcer as a topical antiseptic and compared with the Povidone alone formulation for its influence on healing mechanism.