The main objective of the study was to describe demographics, clinical features and drug prescribing pattern among diabetes mellitus (DM) patients in a south Indian tertiary care hospital. This is a prospective-observational study carried out in a total of 200 patients diagnosed with Type II Diabetes Mellitus in the Department of General Medicine for a period of six months irrespective of age and gender based on inclusion and exclusion criteria. Data of the patients were obtained from Medical Record Department (MRD), and all the data were documented in a suitable designed Case Record Form (CRF).Then data were well analyzed. There were 89 females and 111 males with mean age 60.6±11.2. Most of diabetic patients were male who are qualified with the secondary education (42.5%). Majority of the population (53%) were either alcoholic or smoker and have a duration of diabetes of 5- 10 years(41%).Majority of diabetics (67%) have a family history and incidence is more prevalent in patients with normal bodyweight (54%) with a mean BMI of 24.8 ± 3.3.Majority of the patients (62.5%) had an HbA1C level of 5.7.Most common complication was found to be Retinopathy(21%) and comorbidity for HTN (41%).The majority of patients (44%) received Metformin from class of Biguanide (34.6 %).Insulin preparations accounted for (37 %) of the total anti-diabetic drugs and the most common preparation was Human insulin regular. Monotherapy with either OHA or insulin is dominated over combination therapy and FDC. The studies on drug utilization pattern definitely help the physician to improve the prescribing pattern and efficient clinical management delays the progression of disease, reduce the diabetic related complications and improves the quality of life and for improving clinical outcomes of patientsand better QOL of patients.