HEPATOPROTECTIVE EFFECT OF POLYCARPAEA CORYMBOSA L. AGAINST CCl4 INDUCED HEPATOTOXICITY IN RATS
R. Varadharajan
Professor, Kamalakshi Pandurangan College of Pharmacy, Ayyampalayam, Tiruvannamalai, Tamil Nadu - 606 603, India.
D. Rajalingam
Professor, Kamalakshi Pandurangan College of Pharmacy, Ayyampalayam, Tiruvannamalai, Tamil Nadu - 606 603, India.
Polycarpaea corymbosa L. (family Caryophyllaceae) was first found in the sandhills of Tampa, Florida, in 1960 by O. Lakela. The whole plant of Polycorpaea corymbosa L. are used in Indian traditional medicinal system in inflammatory swellings and in treatment of ulcer, jaundice To investigate the hepatoprotective activity and acute oral toxicity of extract of whole plant of Polycarpaea corymbosa L. (PPC) in male Wistar albino rats by using CCl4 induced hepatoptoxicity. The PPC at doses of 200 and 400mg/kg, p.o and the standard drug Silymarin (100mg/kg, p.o) were administered three times at 12h intervals and then CCl4 (1ml/kg) was administered to all the groups except normal control for 2 days. The hepatoprotective activity was assessed by using various biochemical parameters like SGOT, SGPT, ALP, γ-GT, TP and total bilirubin along with histopathological studies were observed after 36h of CCl4 treatment. The PPC at the doses of 200 and 400mg/kg inhibited CCl4 induced liver toxicity in Wistar albino rats as assessed by the biochemical changes and histopathological studies. The pet ether extract of whole plant of Polycarpaea corymbosa L. afforded significant protection against CCl4 induced hepatocellular injury
2 , 1 , 2012
18 - 23