PHARMACOLOGICAL ASSESSMENT OF HYDRO-ALCOHALIC EXRACT FROM ALPINIA CALCARATA LEAVES ANTIOXIDANT AND ANTI-INFLAMMATORY PROPERTIES
Akila C.R, Samreen SK, Sravani T2, Chaitra B, Swathi B, Preethi vinorika N
Professor, Department of Pharmacology, KLR Pharmacy College, Palwancha, Telangana 507115, India. 2KLR Pharmacy College, Palwancha, Telangana 507115, India
The phytochemical properties of Alpinia calcarata leaves were assessed using hydro-alcoholic extracts to identify and analyze bioactive compounds. The preliminary phytochemical screening revealed the presence of phenols, tannins, carbohydrates, and proteins. The study highlights the importance of understanding plant chemical constituents for the synthesis of complex substances and their potential biological activities. Phenolic compounds and flavonoids in the extracts demonstrated significant antioxidant properties, including cardioprotection and anti-aging effects. Tannins exhibited potential toxicity to fungi, bacteria, and viruses, and are currently being studied in clinical trials for reducing coronary heart disease risk. The antioxidant capacity was evaluated through hydrogen peroxide scavenging and reducing power assays. The hydro-alcoholic extracts displayed good scavenging activity against hydrogen peroxide, which is crucial for antioxidant protection by reducing the rate of chain reactions. The extracts also showed an increase in reducing power with higher concentrations, indicating potential interactions with free radicals to produce stable products. The antiinflammatory properties were examined using the protein denaturation method and membrane stabilization of rabbit red blood cells. The extracts inhibited protein denaturation and stabilized cell membranes in a concentration-dependent manner, suggesting pronounced anti-inflammatory effects in vitro. Alpinia calcarata, a perennial herb traditionally used to treat various ailments, was extracted using ethanol through soxhlet extraction, revealing numerous bioactive constituents. This comprehensive study suggests the potential of Alpinia calcarata leaves for developing antioxidant and antiinflammatory therapeutics
14 , 1 , 2024
01 - 07