169THERAPEUTIC APPROACHES TO TREATING CANCER USING PHARMACOLOGICAL APPROACHESThe development of cancer treatment has changed a lot with the incorporation of high-technological pharmacological strategies that are aimed at changing the molecular and cellular processes that promote the occurrence and growth of tumors. The traditional methods, including chemotherapy and radiotherapy, have been crucial, yet with their limitations (the most noticeable being systemic toxicity and nonspecific cytotoxicity), have led to the creation of more specific therapeutic approaches. Targeted therapies, such as tyrosine kinase inhibitors, monoclonal antibodies, and antibody-drug conjugates, are more specific by targeting aberrant receptors, signaling pathways and oncogenic mutations. Checkpoint inhibitors and PARP inhibitors are immunotherapeutic agents that interfere with anti-tumor and DNA repair vulnerabilities, respectively. Research in genomic profiling, nanotechnology, and artificial intelligence is only improving the personal treatment choice, better drug delivery, and therapeutic responses. Combined, these pharmacological advances have revolutionized the treatment of cancer and enhanced survival rates and decreased morbidity related to treatmentramyasri87428@gmail.comResearch1622026Personalized oncology, Immunotherapy, Synthetic lethality, Targeted therapy, Tyrosine kinase inhibitorsRamya Sri V1*, Harshitha V1, Shaik Suhana Tahrannum1, Diyanka G1, Dr. Purushothaman MPharm. D Intern, Department of Pharmacy Practice, KLR Pharmacy College, Paloncha, Telangana, India